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Atomistry » Palladium » PDB 1ks4-8j8e » 8ejb | |||||||||||||||||||||||||||||||||||||
Atomistry » Palladium » PDB 1ks4-8j8e » 8ejb » |
Palladium in PDB 8ejb: Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-CarboxamideEnzymatic activity of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
All present enzymatic activity of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide:
2.7.10.2; Protein crystallography data
The structure of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide, PDB code: 8ejb
was solved by
S.Gajewski,
M.C.Clifton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8ejb:
The structure of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide also contains other interesting chemical elements:
Palladium Binding Sites:
The binding sites of Palladium atom in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
(pdb code 8ejb). This binding sites where shown within
5.0 Angstroms radius around Palladium atom.
In total only one binding site of Palladium was determined in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide, PDB code: 8ejb: Palladium binding site 1 out of 1 in 8ejbGo back to![]() ![]()
Palladium binding site 1 out
of 1 in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
![]() Mono view ![]() Stereo pair view
Reference:
D.Zhang,
H.M.Harris,
J.Chen,
J.T.Judy,
G.James,
A.Kelly,
J.Mcintosh,
A.Tenn-Mcclellan,
E.R.Ambing,
Y.S.Tan,
H.Lu,
S.Gajewski,
M.C.Clifton,
S.Yung,
D.W.Robbins,
M.Piroozia,
S.S.Skanland,
E.M.Gaglione,
M.Mhibik,
C.Underbayev,
I.Ahn,
C.Sun,
S.E.M.Herman,
M.A.Noviski,
A.Wiestner.
-----Nrx-0492 Degrades Wildtype and C481 Mutant Btk and Demonstrates in Vivo Activity in Cll Patient Derived Xenografts. Blood 2022.
Page generated: Thu Oct 10 10:23:10 2024
ISSN: ESSN 1528-0020 PubMed: 36375120 DOI: 10.1182/BLOOD.2022016934 |
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